Army to undergo testing, Rogers was at last administered the Super-Soldier Serum. Selected by General Chester Phillips of the U.S. The first and the most successful recipient of the Super-Soldier Serum was Steve Rogers. He was now code-named 'Professor Reinstein' to hide his identity. Erskine developed the first 'Super-Soldier Serum' as part of a top secret US Government experiment called Operation: Rebirth. Although the formula was a derivative of the original Super-Soldier Serum that gave Captain America his powers, Lohmer gained abilities exceeding those of Captain America. Master Man (Wilhelm Lohmer) was subjected to the Nazi version of the Super-Soldier Serum. Falsworth escaped the prison and became a costumed fighter of Nazis within Germany itself known as the Destroyer. Falsworth took the disguised flask, drank its contents, and was immediately enhanced by the Super-Soldier formula. Imprisoned by the Nazis and dying, Schmitt asked Brian Falsworth to keep the sample of the Super-Soldier formula he had concealed on his person from falling into the Nazi hands. In the summer of 1941 his Jewish ancestry was discovered by the Red Skull who ordered Schmitt to be taken to a concentration camp. Erskine however defected to the United States of America with the help of Nick Fury, taking his work with him. Their attempts were met with varying success. The also hoped to use Homo mermanus DNA but the mission to retrieve it failed. Abraham Erskine and Professor Eric Schmitt sought to unlock the secrets of Steele's abilities for Project: Nietzsche. John Steele was captured during World War I and his body was kept in stasis at a lab located in Frankfurt, Germany.

So far, it would appear that Captain America (Steve Rogers) is the 'perfect man.' The more powerful variants come with strange side-effects that may also include mental deficiencies.

Variations of the Super-Soldier Serum have been developed over the years which induced greater-mutations than peak human capabilities. Subjects that are considered to have been enhanced to their 'Peak-Potential' are noted to be Captain America, Isaiah Bradley, Josiah X, Protocide via an SSS variant, and Union Jack via a different SSS.

The Super-Soldier Serum is somewhat of a misnomer, as the 'serum' actually consists of various processes.

3.6 Marvel Cinematic Universe (Earth-199999).

3.5 Spider-Man: The Animated Series (Earth-92131).

3.4 The Avengers: Earth's Mightiest Heroes (Earth-8096).

3.2 Weapon X Maverick's home world (Earth-1287).

Captain america super soldier demo